College football fans can use the latest bet365 bonus code CBSBET365 to access either $200 in bonus bets with the placement of a $5+ bet, or get up to a $1,000 first bet safety net. The Week 1 college football schedule is underway, and it includes a matchup between Nevada and Penn State at 3:30 p.m. ET on CBS. The Nittany Lions are 43.5-point favorites against the Wolf Pack, according to the latest Week 1 college football odds at bet365, but SportsLine’s model is backing Nevada to cover the spread in over 50% of simulations.
The model is also backing No. 9 LSU (+4) to cover against No. 4 Clemson in a Week 1 showdown, while the Under (47.5) hits in almost 60% of simulations in a contest between No. 1 Texas and No. 3 Ohio State. Before locking in your Week 1 college football picks on your favorite betting sites like bet365, be sure to check out the top college football betting picks from SportsLine’s proven computer model. Claim the latest bet365 bonus code here, where new users get $200 in bonus bets, or get up to a $1,000 first bet safety net:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks on betting sites could have seen strong returns.
Best Week 1 college football picks:
- LSU (+4) vs. Clemson
- Under 47.5 points in Texas vs. Ohio State
- Alabama (-13.5) vs. Florida State
Combining the model’s three picks into a Week 1 college football parlay at bet365 would result in a payout of +595 (risk $100 to win $595). Bet it at bet365 here:
LSU +4 vs. Clemson
LSU had a 2-2 against-the-spread record as an underdog in 2024. On the same token, Clemson went 5-6 ATS as the favorite and 1-3 ATS against ranked opponents. Garrett Nussmeier is back with the Tigers after throwing for 4,052 passing yards and 29 touchdowns last season. His top target, Aaron Anderson, is also back. Last campaign, he logged 884 receiving yards and five touchdowns. SportsLine’s model is backing LSU to cover the spread in 65% of simulations on Saturday.
Texas vs. Ohio State: Under 47.5 points
These two teams were among the top 3 defenses in college football last season. In 2024, the Buckeyes led the FBS in yards per play (4.19), total defense (254.6), and scoring defense (12.8). Safety Caleb Downs is one of the top players in the nation and logged 81 total tackles, six pass deflections, and two interceptions for the Buckeyes last season. Meanwhile, the Longhorns ranked third in scoring defense (15.3) and total defense (283.4). Texas linebacker Anthony Hill Jr. returns, with 180 total tackles and 13 sacks in his collegiate career. SportsLine’s model projects these teams to score 45 points, aiding the Under to hit in 57% of simulations.
Alabama -13.5 vs. Florida State
The Crimson Tide have 14 starters returning to the team, including receiver Ryan Williams. He racked up 48 catches for 865 receiving yards and eight scores in 2024. Alabama went 7-5 against the spread last season, while the Seminoles were 2-4-1 ATS at home. Florida State also has Thomas Castellanos making his debut after transferring from Boston College. SportsLine’s model is backing Alabama to cover the spread in 58% of simulations, identifying the Crimson Tide as one of its Week 1 college football best bets.
Want more Week 1 college football picks?
You’ve seen the model’s Week 1 college football best bets. Now, get against the spread, total and money-line picks for every Week 1 CFB game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see Week 1 college football picks from legendary college football handicapper Bruce Marshall. Visit SportsLine to see his best bets. SportsLine’s Emory Hunt, who is 45-32 in his last 77 college football picks, has locked in his best bet for Oregon State vs. California right here.
